A Workhorse for 18k: DIY Microscopy with Flexiscope

The Flexiscope is DIY microscope that can be easily converted from upright to inverted configurations in “under 30 minutes”. It’s capable of oblique infrared illumination imaging, multi-channel fluorescent imaging, automated 3D scanning, and even has an electrophysiology configuration. The paper, written by Amy Courtney, Luke Alvey , George Merces, and Mark Pickering which details the […]

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ElectroPen: An ultralow-cost piezoelectric electroporator

Electroporation is a powerful alternative to heat shock for delivering small molecules such as plasmids across cell membranes.  By application of an electrical field netivetly charged DNA is forced into elector-competent cells by an electrohoresis-type effect. Electroporators can be expensive, generally over $2000, hence the popularity of more chemical solutions such as heat shock. Enter […]

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A Blueprint for Cost-Efficient Localization Microscopy

This paper, “A Blueprint for Cost-Efficient Localization Microscopy,” write it’s own summary better than we ever could: “In this study, we questioned every technical high-end component used in standard localization microscopes to reduce the total cost of a wide-field setup and to ensure continued single-molecule sensitivity. We demonstrate that localization microscopy with subdiffraction resolution on […]

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