MesoSPIM: An open-source light-sheet microscope for imaging in cleared tissue

The mesoSPIM (mesoscale selective plane illumination microscopy) project creates open-hardware microscopy platforms for imaging cleared tissue samples. The microscopy setup costs between $170,000 to $240,000 including the optical table and most importantly, the laser itself which will run you between $40,000 to $110,000. This stretches the definition of “On The Cheap”, but the project is […]

Read More

Make Your Own Light Sheet Microscope

Thinking about light sheet microscopy? Openspim.org gives you fantastically detailed assembly instructions to create your very own Selective Plane Illumination Microscope. Credit to Dr. Guillaume Duclos for pointing this resource out. Don’t forget to check out the paper on this project put out by Peter Pitrone, Johannes Schindelin, Luke Stuyvenberg, Stephan Preibisch, Michael Weber, Kevin […]

Read More